Now showing items 1-6 of 6
In Vivo antimalarial activity of aqueous extracts from Kenyan medicinal plants and their chloroquine (CQ) potentiation effects against a blood-induced CQ-resistant rodent parasite in mice
(1Department of Parasitology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan. firstname.lastname@example.org, 2007-04-21)
Hot water extracts from eight medicinal plants representing five families, used for malaria treatment in Kenya were screened for their in vivo antimalarial activity in mice against a chloroquine (CQ) resistant Plasmodium ...
Antimalarial activity of methanolic extracts from plants used in Kenyan ethnomedicine and their interactions with chloroquine (CQ) against a CQ-tolerant rodent parasite, in mice.
(J Ethnopharmacol, 2007-04-20)
Methanolic extracts from 15 medicinal plants representing 11 families, used traditionally for malaria treatment in Kenya were screened for their in vivo antimalarial activity in mice against a chloroquine (CQ)-tolerant ...
Fitness cost of resistance for lumefantrine and piperaquine-resistant Plasmodium berghei in a mouse model
(Gimode et al. Malaria Journal, 2015)
Background: The evolution of drug-resistant parasites is a major hindrance to malaria control, and thus understanding the behaviour of drug-resistant mutants is of clinical relevance. The study aimed to investigate how ...
Novel drug targets in malaria parasite with potential to yield antimalarial drugs with long useful therapeutic lives.
(Curr Pharm Des, 2012)
The status of chemotherapy as the main strategy in malaria control is rapidly being eroded by development of drug resistant Plasmodia, causing malaria to be dubbed a "re-emerging disease". To counter this misfortune, there ...
Genotyping for point mutations in selected codons of pfcrt and pfmdr-1 genes of Plasmodium falciparum among patients with uncomplicated malaria in Mbita district Kenya
(Journal of Natural Sciences Research www.iiste.org, 2014)
Malaria remains a leading cause of morbidity and mortality in Kenya, especially in young children and pregnant women. Due to widespread resistance of Plasmodium falciparum to drugs such as Chloroquine (CQ) and Sulfurdoxi ...
Mapping of DBLα Sequence Tags of Field Isolates from Two Malaria Endemic Sites in Kenya
(Journal of Natural Sciences Research, 2015)
Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) found on the surface of infected erythrocytes (IEs) mediate antigenic variation during P. falciparum infection enabling the parasite evade host immune responses ...